Cyclobutanecarbonyl chloride → HCID 91486271, compound

Reaction equation

[CH:1]1([C:5](Cl)=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH3:8][NH:9][CH:10]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[S:25][C:24]3[C:19](=[N:20][CH:21]=[CH:22][C:23]=3[Cl:26])[CH:18]=2)=[O:16])[CH2:11]1>>[CH3:8][N:9]([CH:10]1[CH2:14][CH2:13][N:12]([C:15]([C:17]2[S:25][C:24]3[C:19](=[N:20][CH:21]=[CH:22][C:23]=3[Cl:26])[CH:18]=2)=[O:16])[CH2:11]1)[C:5]([CH:1]1[CH2:4][CH2:3][CH2:2]1)=[O:6]

Participants

Reactant 2

HCID 78705Cyclobutanecarbonyl chloride

HCID 22278671HCID 22278671, compound

Product 1

HCID 91486271HCID 91486271, compound

Procedure

The title compound was prepared from cyclobutane carbonyl chloride and (3-methylamino-pyrrolidin-1-yl)-(7-chloro-thieno[3,2-b]pyridin-2yl)-methanone by a procedure analogous to Example 64C. MS: 378/380 (MH+); HPLC Rf: 4.71 min.; HPLC purity 98%.

Sources & evidence

ORD record: ord-92e75e88b4264545b7c6f3b74922e1b4
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06964961B2

Reaction notes

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