Pyridine → HCID 23402343, compound
Reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:7](=[O:13])[C@H:8]([CH:10]([CH3:12])[CH3:11])[NH2:9])C.N1C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:14]([N:6]1[CH2:5][C:4](=[O:3])[NH:9][C@@H:8]([CH:10]([CH3:12])[CH3:11])[C:7]1=[O:13])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4.2 gm (14.4 Mol) N-benzyl-N-[(S)-valinyl]glycine ethyl ester and 1.2 mL (0.98 mMol) pyridine in 85 mL toluene was heated at reflux for 3 hours. The reaction mixture was then concentrated under reduced pressure to provide 3.4 gm (96%) of the desired compound as an oily solid.
Workup
- temperatureat reflux for 3 hours
- concentrationThe reaction mixture was then concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-9656edbda238490089920d8b71cb61c9
- Source dataset
- uspto-grants-2005_11
- Patent number
- US06967201B1
Reaction notes
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