HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Chloromethyl)cyclopropane → 2-Cyclopropylmethoxy-4-methoxy-5-thiophen-2-yl-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Chloromethyl)cyclopropane | HCID 80013 | — |
| Reactant | 2-Hydroxy-4-methoxy-5-thiophen-2-yl-benzaldehyde | HCID 11858998 | — |
| Product | 2-Cyclopropylmethoxy-4-methoxy-5-thiophen-2-yl-benzaldehyde | HCID 21980974 | 18% |
Reaction Steps
Ex-32A: 2-Cyclopropylmethoxy-4-methoxy-5-thiophen-2-yl-benzaldehyde was prepared in a similar manner as described in Ex-29C from 2-hydroxy-4-methoxy-5-thiophen-2-yl-benzaldehyde (Ex. 29B) and chloromethyl-cyclopropane, 18% yield. 1H-NMR (CDCl3) δ 10.41 (s, 1H), 8.24 (s, 1H), 7.43 (d, 1H), 7.29 (d, 1H), 7.06 (t, 1H), 6.45 (s, 1H), 3.95 (m, 5H), 1.31 (m, 1H), 0.68 (m, 2H), 0.40 (q, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094801B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-2599c5c31bb8412fa660fff33be023f4 |
| Source note | uspto-grants-2006_08 |