3,4-Dihydro-5-hydroxy-2(1H)-quinolinone → 5-(4-Phenylsulfonyl-butoxy)-3,4-dihydro-carbostyril

Reaction equation

[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][C:6](=[O:12])[NH:7]2.[C:13]1([S:19]([CH2:22][CH2:23][CH2:24][CH2:25]Br)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([S:19]([CH2:22][CH2:23][CH2:24][CH2:25][O:1][C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH2:4][CH2:5][C:6](=[O:12])[NH:7]3)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 1691533,4-Dihydro-5-hydroxy-2(1H)-quinolinone

HCID 114827894-Phenylsulfonylbutyl bromide

Product 1

HCID 205400365-(4-Phenylsulfonyl-butoxy)-3,4-dihydro-carbostyril

Procedure

Prepared analogous to Example 4 from 5-hydroxy-3,4-dihydro-carbostyril and 4-phenylsulfonyl-butyl bromide.

Sources & evidence

ORD record: ord-3f0ad73a6f5e4c3483f0353714c1932c
Source dataset: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04329347

Reaction notes

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