4-oxo-L-proline → 1-[3-[[(4-methoxy)phenylmethyl]thio]-2-trifluoromethyl-1-oxopropyl]-4-oxo-L-proline
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][S:10][CH2:11][CH:12]([C:16]([F:19])([F:18])[F:17])[C:13](Cl)=[O:14])=[CH:5][CH:4]=1.[O:20]=[C:21]1[CH2:25][NH:24][C@H:23]([C:26]([OH:28])=[O:27])[CH2:22]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][S:10][CH2:11][CH:12]([C:16]([F:19])([F:18])[F:17])[C:13]([N:24]2[CH2:25][C:21](=[O:20])[CH2:22][C@H:23]2[C:26]([OH:28])=[O:27])=[O:14])=[CH:5][CH:4]=1Participants
3
Procedure
The 3-[[(4-methoxy)phenylmethyl]thio]-2-trifluoromethylpropionyl chloride from part (a) is reacted with 4-keto-L-proline to yield 1-[3-[[(4-methoxy)phenylmethyl]thio]-2-trifluoromethyl-1-oxopropyl]-4-oxo-L-proline.
Sources & evidence
- ORD record
- ord-4a3f2f29405d4b099b5938e034f8a7eb
- Source dataset
- uspto-grants-1982_05
- DOI