5-Aminoindole → N-(5-Indolyl)-tricyclo[3.3.1.13,7]decane-1-acetamide

HRID 1066237Notes

Reaction equation

HRID 1066237 reaction equation
[C:1]12([CH2:11][C:12](Cl)=[O:13])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][CH:20]=[CH:19]2>>[NH:21]1[C:22]2[C:18](=[CH:17][C:16]([NH:15][C:12](=[O:13])[CH2:11][C:1]34[CH2:10][CH:5]5[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]5)[CH2:2]3)[CH2:8]4)=[CH:24][CH:23]=2)[CH:19]=[CH:20]1

Participants

3

Reactant 2

HCID 788675-AminoindoleHCID 27718821-Adamantaneacetyl chloride

Product 1

HCID 9839604N-(5-Indolyl)-tricyclo[3.3.1.13,7]decane-1-acetamideYield 45.4%

Procedure

Prepared according to the method of Example 1b) from 1-adamantaneacetyl chloride (0.076 g) and 5-aminoindole (0.05 g) to give the title compound as a white solid (0.05 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6d1f53a50f204ce7b4e03585b7fff455
Source dataset
uspto-grants-2001_06
Patent number
US06242470B1

Reaction notes

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