Dibenz(b,f)azepine → Carbamazepine

HRID 1067031Notes

Reaction equation

HRID 1067031 reaction equation
Cl.[NH2:2][C:3]([NH2:5])=[O:4].[CH:6]1[CH:7]=[CH:8][C:9]2N[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH:13]=[CH:12][C:10]=2[CH:11]=1>C(O)(=O)C>[CH:6]1[CH:7]=[CH:8][C:9]2[N:2]([C:3]([NH2:5])=[O:4])[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[CH:13]=[CH:12][C:10]=2[CH:11]=1

Participants

4

Reactant 2

HCID 9212Dibenz(b,f)azepineHCID 101721Urea hydrochloride

Product 1

HCID 2554Carbamazepine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
27.5 °C

Procedure

To a suspension of urea hydrochloride (100 g, 1.036 mols) in acetic acid (125 ml), iminostilbene (25 g, 0.129 mols) was added under stirring at 25-30° C. The resulting reaction mixture was worked up according to the method of Example 1 to produce carbamazepine, which was identical to the product of Example 1.

Workup

  1. additionwas added
  2. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-8e4456a22a7f49ce952b44e08861db61
Source dataset
uspto-grants-2001_06
Patent number
US06245908B1

Reaction notes

Loading…