Cetylpyridinium Chloride → HCID 178443017, compound

HRID 1067165Notes

Reaction equation

HRID 1067165 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N+:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1.[Cl-:23].[CH3:24][N:25]1[N:31]=[C:30]([OH:32])[C:28](=[O:29])[N:27]=[C:26]1[S:33][CH2:34][C:35]1[CH2:56][S:55][C@@H:38]2[C@H:39]([NH:42][C:43](/[C:45](/[C:49]3[N:53]=[C:52]([NH2:54])[S:51][CH:50]=3)=[N:46]\[O:47][CH3:48])=[O:44])[C:40](=[O:41])[N:37]2[C:36]=1[C:57]([OH:59])=[O:58]>O>[CH3:24][N:25]1[N:31]=[C:30]([OH:32])[C:28](=[O:29])[N:27]=[C:26]1[S:33][CH2:34][C:35]1[CH2:56][S:55][C@@H:38]2[C@H:39]([NH:42][C:43](/[C:45](/[C:49]3[N:53]=[C:52]([NH2:54])[S:51][CH:50]=3)=[N:46]\[O:47][CH3:48])=[O:44])[C:40](=[O:41])[N:37]2[C:36]=1[C:57]([OH:59])=[O:58].[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][N+:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[Cl-:23]

Participants

4

Reactant 2

HCID 31239Cetylpyridinium Chloride2×HCID 178502822HCID 178502822, compound2×

Product 1

HCID 178443017HCID 178443017, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

About 210 mg (0.62 mole) of particulate cetyl pyridinium chloride was dissolved in 50 ml of distilled water. Additionally, about 378 mg (0.62 mole) of ceftriaxone was dissolved in 50 ml of a separate volume of distilled water. Next, the ceftriaxone solution was added to the cetyl pyridinium chloride solution and stirred by a magnetic stirrer at room temperature for 1 hour forming a ceftriaxone-cetyl pyridinium chloride solution. About 400 mg of carrageenan was added to the ceftriaxone-cetyl pyridinium chloride solution and the solution was stirred by magnetic stirrer at room temperature for 2 hours. A ceftriaxone-cetyl pyridinium chloride-carrageenan hydrogel complex was formed. The complex was then freeze-dried while in the swollen state, yielding about 0.86 g of the freeze dried complex.

Sources & evidence

ORD record
ord-c1df30ed15824c2681bec1c02e62b7d1
Source dataset
uspto-grants-2001_06
Patent number
US06248360B1

Reaction notes

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