Ethyl cyanoacetate → 2-cyano-N-[3-(dimethylamino)propyl]acetamide
Reaction equation
[C:1]([CH2:3][C:4]([O:6]CC)=O)#[N:2].[CH3:9][N:10]([CH3:15])[CH2:11][CH2:12][CH2:13][NH2:14]>C1(C)C=CC=CC=1>[C:1]([CH2:3][C:4]([NH:14][CH2:13][CH2:12][CH2:11][N:10]([CH3:15])[CH3:9])=[O:6])#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl cyanoacetate (51.106 g, 0.4518 mole) was added to 3-(dimethylamino) propylamine (46.162 g, 0.4518 mole) in a 250 ml round bottom flask equipped with a magnetic stir bar. After stirring for approximately 0.5 hr, 50 ml of toluene was added. The clear orange liquid was stirred at room temperature for approximately 15 hours, after which the ethanol and toluene were removed via vacuum distillation. 2-Cyano-N-[3-(dimethylamino)propyl]acetamide was obtained in 96% yield.
Workup
- customequipped with a magnetic stir bar
- stirringThe clear orange liquid was stirred at room temperature for approximately 15 hours
- customafter which the ethanol and toluene were removed via vacuum distillation
Sources & evidence
- ORD record
- ord-433b1c351aab4497821ec99175586d5b
- Source dataset
- uspto-grants-2001_06
- Patent number
- US06248801B1
Reaction notes
Loading…