Water → 6-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)pyrimidine-4-carboxylic acid methyl ester

HRID 106866

Reaction equation

HRID 106866 reaction equation
[CH2:26]([CH2:27][O:28][CH3:29])[O:30][CH3:31].[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7]([Cl:12])[n:8][c:9]([NH2:11])[cH:10]1.[Cl:13][c:14]1[c:15]([O:24][CH3:25])[c:16]([F:23])[c:17]([B:20]([OH:21])[OH:22])[cH:18][cH:19]1.[OH2:32]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6][c:7](-[c:17]2[c:16]([F:23])[c:15]([O:24][CH3:25])[c:14]([Cl:13])[cH:19][cH:18]2)[n:8][c:9]([NH2:11])[cH:10]1

Participants

5

Reactant 4

HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 441297064-Chloro-2-fluoro-3-methoxyphenylboronic acidHCID 53396493Methyl 6-amino-2-chloropyrimidine-4-carboxylate

Product 1

HCID 594320836-Amino-2-(4-chloro-2-fluoro-3-methoxyphenyl)pyrimidine-4-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-c239059b519d43a6a39738605f2dff48
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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