Sodium Hydroxide → 2-(Pyrimidin-2-yloxy)acetic acid

HRID 1070518

Reaction equation

HRID 1070518 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([O:11]CC)=[O:10].[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([OH:11])=[O:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22396258Ethyl 2-pyrimidinyloxyacetate

Product 1

HCID 5662722-(Pyrimidin-2-yloxy)acetic acidYield 58.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-pyrimidinyloxyacetate (1.4 g) was dissolved in ethanol (10 ml). Sodium hydroxide (2M aq) was added and the mixture was stirred for 64 h. The solvent was evaporated and the residue was dissolved in water, filtered and the acidified with concentrated hydrochloric acid. The resulting precipitate was collected and dried to give the subtitle compound (0.698 g).

Workup

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in water
  3. filtrationfiltered
  4. customThe resulting precipitate was collected
  5. customdried

Sources & evidence

ORD record
ord-fde72d6116224d3081aa845e2d8ee2c7
Source dataset
uspto-grants-2005_06
Patent number
US06903085B1

Linked notes

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