Ethylamine → 29526-66-7
Reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[N+:11]([O-])=O.[CH2:14]([NH2:16])[CH3:15]>C(Cl)Cl>[NH2:11][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:2]=1[CH3:1])[C:6]([NH:16][CH2:14][CH3:15])=[O:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
4-methyl-3-nitro-benzoyl chloride (1.0 g, 5.0 mmol) was dissolved in DCM, and the solution was cooled to 0° C. Ethyl amine (2.0 M in THF, 5.0 mL, 10 mmol) was added dropwise to the acid chloride, and the reaction stirred at 0° C. for 5 min. The ice bath was removed and reaction continued to stir for 3. The solution was washed with brine, dried (Na2SO4), and concentrated in vacuo. The resulting aniline (0.75 g) was used without further purification.
Workup
- customThe ice bath was removed
- customreaction
- stirringto stir for 3
- washThe solution was washed with brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated in vacuo
- customThe resulting aniline (0.75 g) was used without further purification
Sources & evidence
- ORD record
- ord-2dff38dbaa724d6d8ccc0f12cda4885a
- Source dataset
- uspto-grants-2005_06
- Patent number
- US06906067B2
Reaction notes
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