tert-Butyl 4-benzyl-2-methylpiperazine-1-carboxylate → tert-Butyl 2-methylpiperazine-1-carboxylate

HRID 1073164

Reaction equation

HRID 1073164 reaction equation
[CH3:1][CH:2]1[CH2:7][N:6](CC2C=CC=CC=2)[CH2:5][CH2:4][N:3]1[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16].[H][H]>[Pd].CO>[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][N:3]1[C:15]([O:17][C:18]([CH3:19])([CH3:21])[CH3:20])=[O:16]

Participants

5

Reactant 2

HCID 15087789tert-Butyl 4-benzyl-2-methylpiperazine-1-carboxylateHCID 178418361HCID 178418361, compound

Product 1

HCID 15087784tert-Butyl 2-methylpiperazine-1-carboxylateYield 94.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 85 parts of (1,1-dimethylethyl) 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate and 400 parts of methanol was hydrogenated at normal pressure and at room temperature with 3 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 55 parts (94.6%) of (1,1-dimethylethyl) 2-methyl-1-piperazinecarboxylate as a residue (int. 42).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-d57d5fa6cc984cb3a2a756a04080cc7c
Source dataset
uspto-grants-1990_11
Patent number
US04968684

Linked notes

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