HCID 23713292, compound → 6-chloropyridine-2-sulfonic Acid

HRID 1074218

Reaction equation

HRID 1074218 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([O-:11])(=[O:10])=[O:9])[N:3]=1.[Na+]>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8]([OH:11])(=[O:10])=[O:9])[N:3]=1

Participants

3

Reactant 1

HCID 23713292HCID 23713292, compound

Product 1

HCID 27628906-chloropyridine-2-sulfonic AcidYield 96.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Into 0.82 g (3.8 mmol) of sodium 2-chloropyridine-6-sulfonate prepared in accordance with Example 1, 10 ml of concentrated hydrochloric acid was added, and the mixture was stirred at room temperature overnight. Then, the solvent was distilled off, and after an addition of 200 ml of 2-propanol, the residue was heated. Insoluble matters were removed by filtration, and the filtrate was distilled under reduced pressure to obtain 710 mg (96.6%) of 2-chloropyridine-6-sulfonic acid as crystalline solid. Purification was conducted by recrystallization from 2-propanol.

Workup

  1. additionwas added
  2. distillationThen, the solvent was distilled off
  3. additionafter an addition of 200 ml of 2-propanol
  4. temperaturethe residue was heated
  5. customInsoluble matters were removed by filtration
  6. distillationthe filtrate was distilled under reduced pressure

Sources & evidence

ORD record
ord-aa9c7b4c6d564749855d4a6a05427629
Source dataset
uspto-grants-1990_11
Patent number
US04973697

Linked notes

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