4,6-Dimethylpyrimidin-2-ol → 5-Chloro-4,6-dimethyl-pyrimidin-2-ol

HRID 1075162Notes

Reaction equation

HRID 1075162 reaction equation
[Cl:1]Cl.[CH3:3][C:4]1[CH:9]=[C:8]([CH3:10])[NH:7][C:6](=[O:11])[N:5]=1>C(OC(=O)C)(=O)C>[CH3:3][C:4]1[C:9]([Cl:1])=[C:8]([CH3:10])[NH:7][C:6](=[O:11])[N:5]=1

Participants

4

Reactant 2

HCID 95084,6-Dimethylpyrimidin-2-olHCID 24526Chlorine

Product 1

HCID 204942805-Chloro-4,6-dimethyl-pyrimidin-2-ol

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent2×

Procedure

A solution of chlorine (0.01 mol) in acetic anhydride (100 ml) was added to a solution of 4,6-dimethylpyrimid-2-one (0.008 mol) in acetic anhydride (100 ml) and the solution left at room temperature for 1 hr before the solid precipitate was collected and recrystallised from water; m.p. 235° C. (decomp.)

Workup

  1. customwas collected
  2. customrecrystallised from water

Sources & evidence

ORD record
ord-c1dc9053935c423e85228be8e8522698
Source dataset
uspto-grants-1983_07
Patent number
US04395406

Reaction notes

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