5,6-Diamino-1,3-dimethyluracil → 1H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,4-dimethoxyphenyl)ethenyl)-1,3-dimethyl-, (E)-

HRID 1077491

Reaction equation

HRID 1077491 reaction equation
[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=1[NH2:8].[CH3:13][O:14][C:15]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:16]=1[CH:17]=[CH:18][C:19](O)=O>>[CH3:13][O:14][C:15]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:16]=1/[CH:17]=[CH:18]/[C:19]1[NH:1][C:2]2[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 795015,6-Diamino-1,3-dimethyluracilHCID 856363-(2,4-Dimethoxyphenyl)prop-2-enoic acid

Product 1

HCID 64488681H-Purine-2,6-dione, 3,7-dihydro-8-(2-(2,4-dimethoxyphenyl)ethenyl)-1,3-dimethyl-, (E)-Yield 11%

Procedure

Substantially the same procedure as in Reference Example 70 was repeated using 1.0 g (5.88 mmol) of 5,6-diamino-1,3-dimethyluracil and 1.35 g (6.48 mmol) of 2,4-dimethoxycinnamic acid. Then, the resultant crude crystals were recrystallized from dimethylformamide to give 221 mg (yield 11%) of Compound 99 as pale yellow grains.

Workup

  1. customThen, the resultant crude crystals were recrystallized from dimethylformamide

Sources & evidence

ORD record
ord-8c3992dd03e94feea4b42622d098c4ba
Source dataset
uspto-grants-1996_08
Patent number
US05543415

Linked notes

Loading…