3,4-Dimethylbenzoic acid → 3,4-Dimethylbenzoyl chloride

HRID 1078346

Reaction equation

HRID 1078346 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9](O)=[O:10]>>[CH3:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([Cl:3])=[O:10]

Participants

3

Reactant 2

HCID 120733,4-Dimethylbenzoic acidHCID 24386Thionyl Chloride

Product 1

HCID 27585353,4-Dimethylbenzoyl chlorideYield 94.4%

Procedure

78 g of thionyl chloride were added to 50 g of 3,4-dimethylbenzoic acid and the reaction mixture was heated at reflux for 3 hours. The reaction mixture was subsequently concentrated, and the residue was taken up twice in toluene and concentrated again. 53 g of 3,4-dimethylbenzoyl chloride were obtained.

Workup

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux for 3 hours
  3. concentrationThe reaction mixture was subsequently concentrated
  4. concentrationconcentrated again

Sources & evidence

ORD record
ord-10b2432107f14a44882b92f914b359dc
Source dataset
uspto-grants-1996_08
Patent number
US05547967

Linked notes

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