Methyl 4-(chlorosulfonyl)-3-methoxybenzoate → HCID 23364286, compound
Reaction equation
[CH:1]1([N:6]2[C:10]3[CH:11]=[C:12]([O:15][CH2:16][CH3:17])[CH:13]=[CH:14][C:9]=3[NH:8][C:7]2=[O:18])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][O:20][C:21]([C:23]1[CH:28]=[CH:27][C:26]([S:29](Cl)(=[O:31])=[O:30])=[C:25]([O:33][CH3:34])[CH:24]=1)=[O:22]>>[CH:1]1([N:6]2[C:10]3[CH:11]=[C:12]([O:15][CH2:16][CH3:17])[CH:13]=[CH:14][C:9]=3[N:8]([S:29]([C:26]3[CH:27]=[CH:28][C:23]([C:21]([O:20][CH3:19])=[O:22])=[CH:24][C:25]=3[O:33][CH3:34])(=[O:31])=[O:30])[C:7]2=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5]1Participants
3
Procedure
This compound is prepared by the procedure described in EXAMPLE 107 step A) starting from 1 g of 3- cyclopentyl-5-ethoxy-1,3-dihydro-2H-benzimidazol-2-one and 1.2 g of 4-methoxycarbonyl-2-methoxybenzenesulfonyl chloride. It is chromatographed on silica using a DCM/AcOEt mixture (95/5; v/v) as the eluent to give 1.4 g of the expected product. M.p.=151° C.
Workup
- customThis compound is prepared by the procedure
- customIt is chromatographed on silica using a DCM/AcOEt mixture (95/5; v/v) as the eluent