5,6-Diamino-1,3-diethyluracil → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,5-dimethylphenyl)ethenyl)-, (E)-, hydrate (2:1)

HRID 1081779Notes

Reaction equation

HRID 1081779 reaction equation
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][C:16]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:17]=1[CH:18]=[CH:19][C:20](O)=O>>[CH3:15][C:16]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][C:17]=1/[CH:18]=[CH:19]/[C:20]1[NH:1][C:2]2[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 45721335,6-Diamino-1,3-diethyluracilHCID 534015823-(2,5-Dimethylphenyl)prop-2-enoic acid

Product 1

HCID 64488721H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,5-dimethylphenyl)ethenyl)-, (E)-, hydrate (2:1)

Procedure

Substantially the same procedure as in Example 7 was repeated using 3.00 g (15.1 mmol) of 5,6-diamino-1,3-diethyluracil and 3.20 g (18.2 mmol) of 2,5-dimethylcinnamic acid. Then, the resultant crude crystals were recrystallized from ethanol/toluene to give 2.56 g (yield of Compound 96 as white needles.

Workup

  1. customThen, the resultant crude crystals were recrystallized from ethanol/toluene

Sources & evidence

ORD record
ord-8cc502e7aeec416593d534bc341d8bed
Source dataset
uspto-grants-1996_12
Patent number
US05587378

Reaction notes

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