Water → HCID 15003621, compound
Reaction equation
[CH3:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[C:4]([Cl:10])[N:3]=1.[CH3:11][O-:12].[Na+].N1C=CC=NC=1.O>CO>[Cl:10][C:4]1[C:5]([Cl:9])=[C:6]([O:12][CH3:11])[N:7]=[C:2]([CH3:1])[N:3]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution containing 38 g (0.17 mol) of 2-methyl-4,5,6-trichloropyrimidine in 200 ml of methanol was cooled in an ice bath to 10° C.-15° C. and sodium methoxide as a 25 percent solution in methanol was added slowly with stirring until the starting pyrimidine could no longer be detected by GLC analysis. Water was then added and the resulting mixture was extracted with methylene chloride. Removal of the solvent and other volatiles from the extract by evaporation under reduced pressure left the title compound as a white powder melting at 77° C.-78° C.
Workup
- temperaturewas cooled in an ice bath to 10° C.-15° C.
- extractionthe resulting mixture was extracted with methylene chloride
- customRemoval of the solvent and other volatiles from the
- extractionextract by evaporation under reduced pressure
- waitleft the title compound as a white powder melting at 77° C.-78° C.
Sources & evidence
- ORD record
- ord-3894e988d74c4d0e92568bce1d0121ef
- Source dataset
- uspto-grants-1991_04
- Patent number
- US05010195
Reaction notes
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