5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide → Flosequinan

HRID 1085902

Reaction equation

HRID 1085902 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:17])[CH2:13][S:14]([CH3:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>COCCO>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:17])[C:13]([S:14]([CH3:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 867447415'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide

Product 1

HCID 4474062Flosequinan

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A solution of 5'-fluoro-N-methyl-2'-methylsulphinylacetylformanilide (0.77 g) in 2-methoxyethanol (25 ml) was heated to reflux over 20 minutes. After heating under reflux at 128° for 45 minutes the mixture was evaporated in vacuo to give 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone, m.p.225.5°-227° (0.69 g).

Workup

  1. temperatureto reflux over 20 minutes
  2. temperatureAfter heating
  3. temperatureunder reflux at 128° for 45 minutes the mixture
  4. customwas evaporated in vacuo

Sources & evidence

ORD record
ord-6d07a6becd3e4270be25d4f2c5fdfd93
Source dataset
uspto-grants-1991_04
Patent number
US05011931

Linked notes

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