5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide → Flosequinoxan
Reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12](=[O:18])[CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[C:6]([CH:11]=1)[N:7]([CH3:10])[CH:8]=O>COCCO>[F:1][C:2]1[CH:11]=[C:6]2[C:5]([C:12](=[O:18])[C:13]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:8][N:7]2[CH3:10])=[CH:4][CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 5'-fluoro-N-methyl-2'-methylsulphonylacetylformanilide (0.20 g), prepared in a similar manner to that described in Example 11, in 2-methoxyethanol (25 ml) was heated at 97° for 5.3 hours. The mixture was allowed to cool to ambient temperature and then evaporated in vacuo to give 7-fluoro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 234°-235° (0.19 g).
Workup
- temperaturewas heated at 97° for 5.3 hours
- customevaporated in vacuo
Sources & evidence
- ORD record
- ord-8a0f7eaa1a7143279601b127031ddeb0
- Source dataset
- uspto-grants-1991_04
- Patent number
- US05011931
Reaction notes
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