Quinoxalin-6-ylmethanol → Quinoxaline-6-carboxaldehyde

HRID 1086192

Reaction equation

HRID 1086192 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][OH:12])=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1>[O-2].[Mn+4].[O-2].ClCCl>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH:11]=[O:12])=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 6422829Quinoxalin-6-ylmethanol

Product 1

HCID 763958Quinoxaline-6-carboxaldehydeYield 67.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 10 parts of intermediate 5, namely 6-quinoxalinemethanol in 133 parts of dichloromethane were added 20 parts of manganese(IV) oxide. After stirring for 3 hours at room temperature, the reaction mixture was filtered and the filtrate was evaporated, yielding 6.6 parts (67.3%) of 6-quinoxalinecarboxaldehyde; mp. 134° C. (interm. 6).

Workup

  1. filtrationthe reaction mixture was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-65c5ab1fe71e481b8c78200566367692
Source dataset
uspto-grants-1991_07
Patent number
US05028606

Linked notes

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