Amino-6-ethoxybenzothiazole, 2- → N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

HRID 1087472

Reaction equation

HRID 1087472 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH3:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][O:15][CH2:16][C:17](Cl)=[O:18]>N1C=CC=CC=1>[CH2:12]([O:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:1][C:17](=[O:18])[CH2:16][O:15][CH3:14])[S:3][C:4]=2[CH:10]=1)[CH3:13]

Participants

4

Reactant 2

HCID 7192Amino-6-ethoxybenzothiazole, 2-HCID 96623Methoxyacetyl chloride

Product 1

HCID 652526N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-Amino-6-ethoxybenzothiazole (5.8 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting solids are washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (5.1 g) having the following physical properties.

Workup

  1. distillationthe solvent is distilled off
  2. washThe resulting solids are washed with water
  3. dry with materialwith diethyl ether, dried
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-f05414f5b307422c99104486583775b9
Source dataset
uspto-grants-1991_07
Patent number
US05036086

Linked notes

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