Sodium Hydroxide → Minoxidil

HRID 1087882Notes

Reaction equation

HRID 1087882 reaction equation
C([NH:4][C:5]1[N:10]([OH:11])[C:9](=[NH:12])[N:8]=[C:7]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=1)(=O)C.[OH-].[Na+]>C(O)C>[NH2:4][C:5]1[N:10]([OH:11])[C:9](=[NH:12])[N:8]=[C:7]([N:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]2)[CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 140353008HCID 140353008, compound

Product 1

HCID 4201Minoxidil

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0 5 g (2 mmoles) of 6-acetamido-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine prepared as described in Example 6 is dissolved in a mixture containing 10 ml of ethanol and 4 ml of 1N sodium hydroxide solution, the mixture is refluxed for 30 minutes, then evaporated under reduced pressure. After taking up the residue in 10 ml of water, the crystals are filtered, washed with water and dried to give the aimed compound in a yield of 0.35 g (85%), which shows no melting point depression when mixed with the product of Example 1.

Workup

  1. dissolutionis dissolved in a mixture
  2. temperaturethe mixture is refluxed for 30 minutes
  3. customevaporated under reduced pressure
  4. filtrationthe crystals are filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-8e86641f6b2c4d86a1e65c727d246f00
Source dataset
uspto-grants-1990_10
Patent number
US04960888

Reaction notes

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