Sodium Hydroxide → Minoxidil

HRID 1087883

Reaction equation

HRID 1087883 reaction equation
C([NH:4][C:5]1[N:10]([O:11]C(=O)C)[C:9](=[NH:15])[N:8]=[C:7]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:6]=1)(=O)C.[OH-].[Na+]>C(O)C>[NH2:4][C:5]1[N:10]([OH:11])[C:9](=[NH:15])[N:8]=[C:7]([N:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 140353009HCID 140353009, compound

Product 1

HCID 4201Minoxidil

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.0 g (3.4 mmoles) of 6-acetamido-1-acetoxy-1,2-dihydro-2-imino-4-piperidinopyrimidine prepared as described in Example 7 is dissolved in a mixture containing 20 ml of ethanol and 5 ml of 1N aqueous sodium hydroxide solution, the mixture is refluxed for 30 minutes, then evaporated under reduced pressure. Taking up the residue in 10 ml of water, the crystals are filtered, washed with water and dried to give the aimed compound in a yield of 0.54 g (76%), which shows no melting point depression when mixed with the product of Example 1.

Workup

  1. dissolutionis dissolved in a mixture
  2. temperaturethe mixture is refluxed for 30 minutes
  3. customevaporated under reduced pressure
  4. filtrationthe crystals are filtered
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-bd0a4a8219f34b3488950ee14ff77a09
Source dataset
uspto-grants-1990_10
Patent number
US04960888

Linked notes

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