Desmethylnaproxen → alpha-Methyl-6-[(2-phenyl-4-thiazolyl)methoxy]-2-naphthaleneacetic acid

HRID 1087906

Reaction equation

HRID 1087906 reaction equation
[C:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12]Cl)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([CH:25]([CH3:29])[C:26]([OH:28])=[O:27])[CH:19]=[CH:18]2>>[CH3:29][CH:25]([C:20]1[CH:19]=[CH:18][C:17]2[C:22](=[CH:23][CH:24]=[C:15]([O:14][CH2:12][C:10]3[N:11]=[C:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[S:8][CH:9]=3)[CH:16]=2)[CH:21]=1)[C:26]([OH:28])=[O:27]

Participants

3

Reactant 2

HCID 162920DesmethylnaproxenHCID 2369694-(Chloromethyl)-2-phenyl-1,3-thiazole

Product 1

HCID 15030188alpha-Methyl-6-[(2-phenyl-4-thiazolyl)methoxy]-2-naphthaleneacetic acid

Procedure

The title compound is prepared according to the method of Example 7 using 2-phenyl-4-(chloromethyl)thiazole and racemic 6-hydroxy-α-methyl-2-naphthalene acetic acid. White crystals are obtained having a melting point of 163°-164° C.

Workup

  1. customWhite crystals are obtained

Sources & evidence

ORD record
ord-1add32cd1e354a7f8b84270cd9cdd94d
Source dataset
uspto-grants-1990_10
Patent number
US04960892

Linked notes

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