1-Iodopentane → alpha-Methyl-6-(pentyloxy)-2-naphthaleneacetic acid

HRID 1087909

Reaction equation

I[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[CH:14]=[C:13]([CH:18]([CH3:22])[C:19]([OH:21])=[O:20])[CH:12]=[CH:11]2>>[CH3:22][CH:18]([C:13]1[CH:12]=[CH:11][C:10]2[C:15](=[CH:16][CH:17]=[C:8]([O:7][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH:9]=2)[CH:14]=1)[C:19]([OH:21])=[O:20]

Participants

Reactant 2

HCID 123351-Iodopentane

HCID 162920Desmethylnaproxen

Product 1

HCID 15030191alpha-Methyl-6-(pentyloxy)-2-naphthaleneacetic acid

Procedure

The title compound is prepared according to the method of Example 7 using 1-iodopentane and racemic 6-hydroxy-α-methyl-2-naphthalene acetic acid. White crystals are obtained having a melting point of 97°-99° C.

Workup

customWhite crystals are obtained

Sources & evidence

ORD record: ord-c55212f2d70a4e8da4aeaecf8aa5baf7
Source dataset: uspto-grants-1990_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04960892

Linked notes

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