Etidronic Acid → ZINC oxide ZINC etidronate

HRID 1089374

Reaction equation

HRID 1089374 reaction equation
[CH3:1][C:2]([P:8]([OH:11])([OH:10])=[O:9])([P:4]([OH:7])([OH:6])=[O:5])[OH:3].[O-2].[Zn+2:13]>>[O-2:3].[Zn+2:13].[Zn:13].[CH3:1][C:2]([P:8]([OH:11])([OH:10])=[O:9])([P:4]([OH:7])([OH:6])=[O:5])[OH:3]

Participants

3

Reactant 2

HCID 3305Etidronic Acid2×HCID 3007857Zinc Oxide3×

Product 1

HCID 131716685ZINC oxide ZINC etidronate

Procedure

First, 1030 g of a solution of etidronic acid (206 g as etidronic acid) was heated to 70° C. and 2035 g of a zinc oxide slurry (407 g as zinc oxide) held at 70° C. was added dropwise over about 2 hours with stirring. The mol ratio of zinc oxide to etidronic acid was 5/1. This slurry was stirred at 60° to 70° C. for 5 hours and, then, cooled to room temperature. The slurry was filtered and the dehydrated cake was washed with distilled water 3 to 5 times and, then, subjected to dehydration, drying and pulverization to give a zinc oxide/zinc etidronate composition.

Workup

  1. customheld at 70° C.
  2. additionwas added dropwise over about 2 hours
  3. stirringThis slurry was stirred at 60° to 70° C. for 5 hours
  4. filtrationThe slurry was filtered
  5. washthe dehydrated cake was washed with distilled water 3 to 5 times
  6. customdrying

Sources & evidence

ORD record
ord-0f790ef0dc3f4b8e9504bfd767e6af12
Source dataset
uspto-grants-1990_10
Patent number
US04966630

Linked notes

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