Ethanol → HCID 14699637, compound
Reaction equation
[F:1][C:2]1([Cl:9])[CH2:4][C:3]1([CH3:8])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:15](O)[CH3:16]>>[F:1][C:2]1([Cl:9])[CH2:4][C:3]1([CH3:8])[C:5]([O:7][CH2:15][CH3:16])=[O:6]Participants
4
Procedure
44 ml of ethanol are added at room temperature and with stirring to 43 g (0.28 mol) of 2-fluoro-2-chloro-1-methyl-cyclopropanecarboxylic acid. After the addition of sulphuric acid, the reaction mixture is refluxed for 16 hours. Excess ethanol is subsequently distilled off and the residue is dried and distilled under reduced pressure. In this manner, 40 g (79% of theory) of ethyl 2-fluoro-2-chloro-1-methyl-cyclopropane-carboxylate are obtained in the form of a liquid of boiling point 62°-63° C./17 mbar.
Workup
- temperaturethe reaction mixture is refluxed for 16 hours
- distillationExcess ethanol is subsequently distilled off
- customthe residue is dried
- distillationdistilled under reduced pressure
Sources & evidence
- ORD record
- ord-454a7881f5974cbea382d5b033bcad1f
- Source dataset
- uspto-grants-1992_01
- Patent number
- US05081283
Reaction notes
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