2-(2-Aminophenyl)isoindole-1,3-dione → HCID 178450491, compound

HRID 1090668

Reaction equation

HRID 1090668 reaction equation
[C:1]1(=[O:18])[N:5]([C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[NH2:8])[C:4](=[O:13])[C:3]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:2]12.[C:19]([C:24](=[CH:30]OCC)[C:25]([O:27][CH2:28][CH3:29])=[O:26])(=[O:23])[CH2:20][CH2:21][CH3:22]>CCOCC>[C:19]([C:24](=[CH:30][NH:8][C:7]1[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=1[N:5]1[C:4](=[O:13])[C:3]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:2]2[C:1]1=[O:18])[C:25]([O:27][CH2:28][CH3:29])=[O:26])(=[O:23])[CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 6736762-(2-Aminophenyl)isoindole-1,3-dioneHCID 3359484Ethyl 2-butyryl-3-ethoxyacrylate

Product 1

HCID 178450491HCID 178450491, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-Phthalimidoaniline (44.0 g, 0.21 moles) and ethyl 2-butyryl-3-ethoxyacrylate (45 g, 0.21 moles) were heated together in fusion for 10 minutes then allowed to cool, forming a tan solid. The ethyl 2-buryryl-3-(2-phthalimidophenylamino)acrylate (83.0 g, 97%) was stirred in ether, filtered and dried under vacuum, m.p 153°-5° C.

Workup

  1. temperatureto cool
  2. customforming a tan solid
  3. filtrationfiltered
  4. customdried under vacuum, m.p 153°-5° C.

Sources & evidence

ORD record
ord-8929377535d145a9aabccc39fa559cd9
Source dataset
uspto-grants-1992_01
Patent number
US05082841

Linked notes

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