N-Acetyl-D-Galactosamine → D-Glucuronic Acid

HRID 1091217Notes

Reaction equation

OC1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O.C1C(=O)NC(=O)N([C@@H]2O[C@H](COP(OP([O:38][C@H:39]3[O:44][C@H:43]([C:45]([O-:47])=[O:46])[C@@H:42]([OH:48])[C@H:41]([OH:49])[C@H:40]3[OH:50])([O-])=O)([O-])=O)[C@@H](O)[C@H]2O)C=1.[Na+].[Na+].[Na+]>>[OH:38][CH:39]1[O:44][C@H:43]([C:45](=[O:46])[OH:47])[C@@H:42]([OH:48])[C@H:41]([OH:49])[C@H:40]1[OH:50]

Participants

Reactant 2

HCID 35717N-Acetyl-D-Galactosamine

HCID 16220076UDP-GlcA

Product 1

HCID 94715D-Glucuronic Acid

Procedure

Saccharide chain fractions were prepared in the same manner as that of (A) except that UDP-GlcA was used instead of UDP-GalNAc to prepare sample solutions for MS.

Workup

customto prepare sample solutions for MS

Sources & evidence

ORD record: ord-cd6c521b316c41d89e63f0f50318c904
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08129148B2

Reaction notes

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