2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine → HCID 58007608, compound
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[C:4]([CH2:9][CH3:10])[CH:3]=1.[F:11][C:12]([F:23])([F:22])[C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][NH2:21])=[N:17][CH:18]=1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:21][CH2:20][CH2:19][C:16]2[CH:15]=[CH:14][C:13]([C:12]([F:23])([F:11])[F:22])=[CH:18][N:17]=2)=[CH:3][C:4]=1[CH2:9][CH3:10]Participants
3
Procedure
In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (4-chloro-3-ethyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 329.2 [M+H]+) was prepared from 4-bromo-1-chloro-2-ethylbenzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.
Workup
- customIn analogy to the procedure described for the synthesis example 71 (step 1)