4-Nitroisophthalic acid → 4-Aminobenzene-1,3-dioic acid

HRID 1094730

Reaction equation

HRID 1094730 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[C:13]([OH:15])=[O:14])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][C:5]=1[C:13]([OH:15])=[O:14]

Participants

4

Reactant 1

HCID 30624384-Nitroisophthalic acid

Product 1

HCID 113558524-Aminobenzene-1,3-dioic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 4-nitro isophthalic acid (4 g, 18.95 mmol) in MeOH (200 mL) was added Pd/C (20%) and the mixture was hydrogenated at RT over night. The reaction mixture was filtered through Celite and filtrate concentrated under vacuum to give 4-amino isophthalic acid in 60% as a solid.

Workup

  1. waitthe mixture was hydrogenated at RT over night
  2. filtrationThe reaction mixture was filtered through Celite and filtrate
  3. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-a70aad4b64f84b4ba0494f54b48628cb
Source dataset
uspto-grants-2012_03
Patent number
US08133998B2

Linked notes

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