HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl squarate → Methyl (2S)-3-{3'-[(2-ethoxy-3,4-dioxo-1-cyclobuten-1-yl) amino][1,1'-biphenyl]-4-yl}-2-mesitylsulfonylamino-propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl squarate | HCID 123228 | — |
| Reactant | Methyl (2S)-3-(3'-amino[1,1'-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate | HCID 11430900 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | Methyl (2S)-3-{3'-[(2-ethoxy-3,4-dioxo-1-cyclobuten-1-yl) amino][1,1'-biphenyl]-4-yl}-2-mesitylsulfonylamino-propanoate | HCID 56989219 | 59% |
Reaction Steps
2 g of Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate 12.1.2 were mixed with 0.75 g 3,4-diethoxy-3-cyclobuten-1,2-dion in 40 ml 1 propanol and refluxed for 20 h. Purification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1) yielded 1,5 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094911B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-eeba8983ef704b9db8cf16948c3268c1 |
| Source note | uspto-grants-2006_08 |