HCID 178420353, compound → HCID 178511580, compound
Reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[O:18]1[CH2:17][CH2:16][N:15]([C@H:12]2[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]2)[CH2:20][CH2:19]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
7.2 g (16.4 mmol) of trans-dibenzyl-4-morpholino-cyclohexylamine are dissolved in 100 mL of MeOH and hydrogenated on 1.4 g of Pd/C (10%) at 30-50° C. The solvent is eliminated in vacuo and the residue is crystallised from ethanol and concentrated HCl.
Workup
- customthe residue is crystallised from ethanol and concentrated HCl
Sources & evidence
- ORD record
- ord-ebc29fad280c407d8638f9ce4b4345c7
- Source dataset
- uspto-grants-2012_03
- Patent number
- US08143247B2
Reaction notes
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