3-Phenoxy-1,2-propanediol → Phenoxyacetaldehyde

HRID 1098840Notes

Reaction equation

HRID 1098840 reaction equation
I([O-])(=O)(=O)=O.[Na+].[O:7]([CH2:14][CH:15]([OH:18])CO)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[O:7]([CH2:14][CH:15]=[O:18])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 108573-Phenoxy-1,2-propanediolHCID 23667635Sodium periodate

Product 1

HCID 75033PhenoxyacetaldehydeYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Sodium periodate (0.65 M in water, 20 mL) was added to a vigorously stirred suspension of silica gel (20 g) in dichloromethane (160 mL), followed by a solution of 3-phenoxy-1,2-propanediol (1.68 g, 10.0 mmol) in dichloromethane (20 mL). After stirring for 10 min the mixture was filtered and the filtrate was concentrated to give the subtitle compound (1.36 g, 100%).

Workup

  1. filtrationwas filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-15b9268a4a2f477988dae515e9076246
Source dataset
uspto-grants-2012_03
Patent number
US08143290B2

Reaction notes

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