N-2',4',6'-Trimethoxyphenacyl bromide → HCID 57693765, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][SH:10])=[CH:5][C:4]=1[N+:11]([O-:13])=[O:12].Br[CH2:15][C:16]([C:18]1[C:23]([O:24][CH3:25])=[CH:22][C:21]([O:26][CH3:27])=[CH:20][C:19]=1[O:28][CH3:29])=[O:17]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][S:10][CH2:15][C:16]([C:18]2[C:19]([O:28][CH3:29])=[CH:20][C:21]([O:26][CH3:27])=[CH:22][C:23]=2[O:24][CH3:25])=[O:17])=[CH:5][C:4]=1[N+:11]([O-:13])=[O:12]Participants
3
Procedure
According to Scheme 5, (4-methoxy-3-nitrophenyl)methanethiol 10 (an aromatic mercaptan according to Formula IIb) is reacted with 2-bromo-1-(2,4,6-trimethoxyphenyl)ethanone (a compound according to Formula IIa) to form 2-(4-methoxy-3-nitrobenzylthio)-1-(2,4,6-trimethoxyphenyl)ethanone 11 (a sulfide according to Formula II). Suitable reaction conditions for this reaction are as described above for the reaction of a Formula IIa compound and a Formula IIb compound.
Sources & evidence
- ORD record
- ord-06be1d5d419842b0848f791af9d883a0
- Source dataset
- uspto-grants-2012_03
- DOI