2-Hydroxy-4-Methoxybenzaldehyde → 3-(4-methoxybenzylsulfonyl)-7-methoxy-2H-chromen-2-one

HRID 1099722

Reaction equation

HRID 1099722 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:11])[C:6](=[CH:9][CH:10]=1)[CH:7]=O.[CH3:12][O:13][C:14]1[CH:27]=[CH:26][C:17]([CH2:18][S:19]([CH2:22][C:23](O)=[O:24])(=[O:21])=[O:20])=[CH:16][CH:15]=1>C(O)(=O)C>[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:18][S:19]([C:22]2[C:23](=[O:24])[O:11][C:5]3[C:6]([CH:7]=2)=[CH:9][CH:10]=[C:3]([O:2][CH3:1])[CH:4]=3)(=[O:20])=[O:21])=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 696002-Hydroxy-4-MethoxybenzaldehydeHCID 120974144-Methoxybenzyl-sulfonylacetic acid

Product 1

HCID 115377793-(4-methoxybenzylsulfonyl)-7-methoxy-2H-chromen-2-oneYield 43%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 4-methoxysalicylaldehyde (1 mmol) and 2-(4-methoxybenzylsulfonyl)acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 2, Method A to generate a 43% yield of the title compound; m.p. 179-180° C.

Sources & evidence

ORD record
ord-e8a86f6410794085a1271fc5d94abea0
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Linked notes

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