2,4-Dihydroxybenzaldehyde → 3-(4-methoxybenzylsulfonyl)-7-hydroxy-2H-chromen-2-one

HRID 1099723

Reaction equation

HRID 1099723 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([OH:10])[C:5](=[CH:8][CH:9]=1)[CH:6]=O.[CH3:11][O:12][C:13]1[CH:26]=[CH:25][C:16]([CH2:17][S:18]([CH2:21][C:22](O)=[O:23])(=[O:20])=[O:19])=[CH:15][CH:14]=1>C(O)(=O)C>[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:17][S:18]([C:21]2[C:22](=[O:23])[O:10][C:4]3[C:5]([CH:6]=2)=[CH:8][CH:9]=[C:2]([OH:1])[CH:3]=3)(=[O:19])=[O:20])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 72132,4-DihydroxybenzaldehydeHCID 120974144-Methoxybenzyl-sulfonylacetic acid

Product 1

HCID 116459323-(4-methoxybenzylsulfonyl)-7-hydroxy-2H-chromen-2-oneYield 30%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 4-hydroxysalicylaldehyde (1 mmol) and 2-(4-methoxybenzylsulfonyl)acetic acid (1 mmol) in acetic acid (10 mL) was subjected to the General Procedure 2, Method A to generate a 30% yield of the title compound; m.p. 231-232° C.

Sources & evidence

ORD record
ord-64275772986e4f7ba74b8617faa798b3
Source dataset
uspto-grants-2012_03
Patent number
US08143428B2

Linked notes

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