2,2',4'-Trichloroacetophenone → HCID 178456953, compound
Reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:3]=1[C:4](=O)[CH2:5]Cl.[CH2:13]([NH:16][C:17](=[S:20])[NH:18][NH2:19])[CH2:14][CH3:15]>CO>[ClH:1].[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:3]=1[C:4]1[CH2:5][S:20][C:17]([NH:16][CH2:13][CH2:14][CH3:15])=[N:18][N:19]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
6.70 g (0.03 mole) of 2,4-dichlorophenacyl chloride and 3.99 g (0.03 mole) of 4-n-propyl-thiosemicarbazide are reacted in 150 ml of methanol under the conditions of Example 2. The concentrated product is crystallized and then recrystallized from methanol/ethyl acetate, to produce 6.4 g of 5-(2,4-dichlorophenyl)-N-propyl-6H-1,3,4-thiadiazin-2-amine monohydrochloride. m.p. 184°-185° C. The product is then dried at 65° C. under high vacuum.