HCID 178493728, compound → HCID 178512636, compound
Reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]2[C:18](=[O:19])[C:17](=[O:20])[C:16]=2OC)[N:9]=1)[C:2]([NH2:4])=[NH:3]>CO>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:16]2[C:17](=[O:20])[C:18](=[O:19])[C:15]=2[NH:14][CH2:13][CH2:12][CH2:11][CH2:10][C:8]2[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 2-quanidino-4-(4-aminobutyl)thiazole (0.105 g) and 1-[4-(2-guanidinothiazol-4-yl)butylamino]-2-methoxycyclobutene-3,4-dione (0.16 g) in dry methanol (5 ml) was stirred for 18 hours at room temperature. The white solid was filtered off, washed with methanol and dried in vacuo to give 1,2-bis[4-(2-guanidinothiazol-4-yl)-butylamino]cyclobutene-3,4-dione, 0.16 g., m.p. 228°-229° C.
Workup
- filtrationThe white solid was filtered off
- washwashed with methanol
- customdried in vacuo