Methoxycarbonyl isothiocyanate → 3-(3-Acetylthioureido)-4-(3-carbomethoxythioureido)benzophenone
Reaction equation
[C:1]([NH:4][C:5](=[S:22])[NH:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[NH2:21])[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11])(=[O:3])[CH3:2].[C:23]([N:27]=[C:28]=[S:29])([O:25][CH3:26])=[O:24]>CC(C)=O>[C:1]([NH:4][C:5](=[S:22])[NH:6][C:7]1[CH:8]=[C:9]([CH:18]=[CH:19][C:20]=1[NH:21][C:28]([NH:27][C:23]([O:25][CH3:26])=[O:24])=[S:29])[C:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:11])(=[O:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension of 3-(3-acetylthioureido)-4-aminobenzophenone (1.1 g.) in acetone (15 ml.) is added carbomethoxy isothiocyanate (0.41 g.). The mixture is heated to reflux and then is stirred at room temperature for 18 hours. The crude product is collected by filtration, washed with acetone and ether and then dried to afford 0.6 g. (40% yield) of 3-(3-acetylthioureido)-4-(3-carbomethoxythioureido)benzophenone, m.p. 203°-204° C., dec.