1-(3-Bromopropoxy)-4-fluorobenzene → Tert-butyl 4-{4-[3-(4-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate

HRID 110586

Reaction equation

HRID 110586 reaction equation
[Br:22][CH2:23][CH2:24][CH2:25][O:26][c:27]1[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]1.[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([OH:14])[cH:12][cH:13]1>>[OH:1][CH:2]1[CH2:3][N:4]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:5][CH2:6][CH:7]1[c:8]1[cH:9][cH:10][c:11]([O:14][CH2:23][CH2:24][CH2:25][O:26][c:27]2[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]2)[cH:12][cH:13]1

Participants

3

Reactant 2

HCID 2600041-(3-Bromopropoxy)-4-fluorobenzeneHCID 21713087(3S,4S)-tert-Butyl 3-hydroxy-4-(4-hydroxyphenyl)piperidine-1-carboxylate

Product 1

HCID 68501103Tert-butyl 4-{4-[3-(4-fluorophenoxy)propoxy]phenyl}-3-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record
ord-f6671d791a8c4df5a2c4008349a1c325
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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