3-Acetylpyridine → Ethyl 2-(2-Butyl)-3-hydroxy-3-methyl-3-(3-pyridyl)propionate

HRID 1106196

Reaction equation

[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[CH3:10][CH:11]([CH2:18][CH3:19])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[CH3:10][CH:11]([CH:12]([C:1]([OH:3])([CH3:2])[C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:18][CH3:19]

Participants

Reactant 2

HCID 95893-Acetylpyridine

HCID 560255Ethyl 3-methylpentanoate

Product 1

HCID 54531343Ethyl 2-(2-Butyl)-3-hydroxy-3-methyl-3-(3-pyridyl)propionate

Procedure

Analysis of the pyrolysis product mixture by gas chromatography and preparative thin layer chromatography indicates that the mixture consists of 12 milligrams of the hydroxy ester starting material, and 85 milligrams of a 1:1 mixture of 3-acetylpyridine and ethyl β-methylvalerate.

Sources & evidence

ORD record: ord-9856087d169d4c7f9a4c2cd044160d48
Source dataset: uspto-grants-1982_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04312368

Linked notes

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