Reaction equation
[C:1]([O:18]C)(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH2:27]([N:26]([CH2:25][CH2:24][O:23][CH2:22][CH2:21][OH:20])[C:1](=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
Into a 250 ml-flask equipped with reflux condenser, were introduced 14.3 g of methyl palmitate and 16.5 g of N-(2-hydroxyethoxy)ethyl-n-hexadecyl amine prepared in Example 1, and thereto was added 2.6 g of sodium carbonate. Then, the mixture was stirred violently for 3 hours at 120° C. After the termination of the reaction, the mixture was cooled to a room temperature and 100 ml of chloroform was added thereto to be dissolved. The precipitates were removed and the solvent was evaporated off under reduced pressure. The produced solid was recrystallized from hexane to give 23.2 g of the title compound(Yield: 82%) as white powder, which was identified by IR and NMR. The results are shown in Table 1.
Workup
- customInto a 250 ml-flask equipped
- temperaturewith reflux condenser
- customAfter the termination of the reaction
- temperaturethe mixture was cooled to a room temperature
- dissolutionto be dissolved
- customThe precipitates were removed
- customthe solvent was evaporated off under reduced pressure
- customThe produced solid was recrystallized from hexane
Sources & evidence
- ORD record
- ord-6c9600fb39bd4a628153c4c9393e2866
- Source dataset
- uspto-grants-2000_05
- Patent number
- US06060612
Linked notes
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