2,4-Dichlorobenzyl alcohol → 1-(2-Butenyl)-7-(2,4-dichlorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazine

HRID 1107752

Reaction equation

HRID 1107752 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[Cl:17][C:18]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:19]=1[CH2:20][OH:21]>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:21][CH2:20][C:19]3[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:18]=3[Cl:17])[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 156842,4-Dichlorobenzyl alcoholHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 543778711-(2-Butenyl)-7-(2,4-dichlorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazineYield 72.4%

Procedure

The title compound (cis/trans=25/75) was prepared as white crystals in 72.4% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=21/79) and 2,4-dichlorobenzyl alcohol.

Sources & evidence

ORD record
ord-4651c09e6f5542d19f03aaab74906ae1
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Linked notes

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