2,4-Difluorobenzyl alcohol → 1-(2-Butenyl)-7-(2,4-difluorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazine

HRID 1107753

Reaction equation

HRID 1107753 reaction equation
[CH2:1]([N:5]1[C:9]2=[C:10](Cl)[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4].[F:17][C:18]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:19]=1[CH2:20][OH:21]>>[CH2:1]([N:5]1[C:9]2=[C:10]([O:21][CH2:20][C:19]3[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:18]=3[F:17])[N:11]=[N:12][CH:13]=[C:8]2[C:7]([CH3:15])=[C:6]1[CH3:16])[CH:2]=[CH:3][CH3:4]

Participants

3

Reactant 2

HCID 918672,4-Difluorobenzyl alcoholHCID 537196241-(2-Butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine

Product 1

HCID 539103741-(2-Butenyl)-7-(2,4-difluorobenzyloxy)-2,3-dimethylpyrrolo[2,3-d]pyridazineYield 43.1%

Procedure

The title compound (cis/trans=18/82) was prepared as a pale yellow powder in 43.1% yield in a similar procedure to that described in Example 1 by using 1-(2-butenyl)-7-chloro-2,3-dimethylpyrrolo[2,3-d]pyridazine (cis/trans=21/79) and 2,4-difluorobenzyl alcohol.

Sources & evidence

ORD record
ord-5028f0128512400995d3b0e575ddb826
Source dataset
uspto-grants-2000_05
Patent number
US06063782

Linked notes

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