Ammonia → 3-Methoxy-5-methylpyrazine-2-carboxamide

HRID 1108449

Reaction equation

[CH3:1][O:2][C:3]1[C:4]([C:10]([O:12]C)=O)=[N:5][CH:6]=[C:7]([CH3:9])[N:8]=1.[NH3:14]>>[CH3:1][O:2][C:3]1[C:4]([C:10]([NH2:14])=[O:12])=[N:5][CH:6]=[C:7]([CH3:9])[N:8]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 21702987Methyl 3-methoxy-5-methylpyrazine-2-carboxylate

Product 1

HCID 110627763-Methoxy-5-methylpyrazine-2-carboxamideYield 87%

Conditions

Temperature: 50 °C

Procedure

1 g (5.5 mmol) of methyl 3-methoxy-5-methylpyrazine-carboxylate was initially charged in 15 ml (198 mmol) of NH3 (25%) and the mixture was stirred at 50° C. After concentration, 0.8 g of 3-methoxy-5-methylpyrazine-2-carboxamide was obtained. The yield was 86 percent. Other data concerning the title product was:

Workup

concentrationAfter concentration

Sources & evidence

ORD record: ord-93160725dc4f4913922cf20cc4f7a314
Source dataset: uspto-grants-2000_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06066736

Linked notes

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