Formaldehyde → 3-Morpholino-2-(2-pyrimidyl)propionitrile
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]#[N:9].[CH2:10]=O.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CO>[O:15]1[CH2:16][CH2:17][N:12]([CH2:10][CH:7]([C:2]2[N:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:8]#[N:9])[CH2:13][CH2:14]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
The above prepared 2-(2-pyrimidyl)acetonitrile is reacted with formaldehyde and morpholine in methanol to give 3-morpholino-2-(2-pyrimidyl)propionitrile.
Sources & evidence
- ORD record
- ord-a6d473b91d574987b5429fbe2f6a2ddb
- Source dataset
- uspto-grants-1978_10
- Patent number
- US04118567
Reaction notes
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